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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: DNA double-strand break (DSB) is generally regarded as the most lethal of all DNA lesions after radiationKu80, DNA-PK catalytic subunit (DNA-PKcs) and ataxia telangiectasia mutated (ATM) proteins are majorand ATM protein.We found that the expression of same protein in different cell lines and the expression of three proteinsThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: The Fc fragment of the IgG-binding protein (FCGBP) was identified as the most promising indicator of

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein    

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Molecular simulation of the interaction mechanism between CodY protein and DNA in

Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 133-139 doi: 10.1007/s11705-018-1737-4

Abstract: In , the global transcriptional regulatory factor CodY can interact with the promoter DNA to regulateIn order to study the mechanism of interaction between CodY and its target DNA, molecular docking andmolecular dynamics simulations were used to explore the binding process at molecular level.Through the calculations of the free energy of binding, hydrogen bonding and energy decomposition, ninebinding.

Keywords： CodY     DNA     molecular docking     molecular dynamics    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: The aggregation of amyloid -protein (A ) is tightly linked to the pathogenesis of Alzheimer’s diseaseHowever, atomic details of binding modes and binding affinities between these peptide inhibitors andAll inhibitors exhibit varied binding affinity to A , in which KLVFF has the highest binding affinityThis work provides structure-based binding information for further modification and optimization of thesethree peptide inhibitors to enhance their binding and inhibitory abilities against A aggregation.

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: We constructed a eukaryotic expression plasmid encoding Epstein-Barr virus latent membrane protein 2It was employed to evaluate immune response of the mice inoculated doubly with the DNA vaccine.The serum titer of IgG antibody against LMP2 epitope in the mice immunized with the DNA vaccine encodingIn conclusion, the EBV DNA vaccine can induce a strong humoral immune response in mice.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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Anti RNA Viruses Related Biomaterials

Yao Kangde,Yin Yuji,Zhang Baolian,Zhao Liguo

Strategic Study of CAE 2003, Volume 5, Issue 7,   Pages 17-23

Abstract: Antivirus strategies including design of anti - SARS drugs, RNA interference, DNA vaccine delivery systemThese examples imply the interactions of RNA viruses with proteins, DNA, and polysaccharides.

Keywords： Anti-RNA viruses     protein     DNA     polysaccharide     biomaterials    

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Protein adsorption in two-dimensional electrochromatography packed with superporous and microporous cellulose

Dongmei WANG, Guodong JIA, Liang XU, Xiaoyan DONG, Yan SUN

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 229-234 doi: 10.1007/s11705-009-0213-6

Abstract: The dynamic binding capacity (DBC) in the presence of 2D eEF was higher than in the presence of a one-dimensional2D electrochromatography packed with the superporous cellulose adsorbent is promising for high-speed protein

Keywords： electrochromatography     two-dimensional electric field     dynamic binding capacity     superporous cellulose bead     protein    

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Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 97-104 doi: 10.15302/J-FASE-2018248

Abstract:

Plant nucleotide binding domain and leucine-rich repeat (NLR) receptors recognize pathogen effectorsThe N-end rule pathway of protein degradation is also directly linked to NLR stability.

Keywords： E3 ubiquitin ligase     degradation     nucleotide-binding leucine-rich repeat receptor     plant immunity     proteasome     protein stability     ubiquitination    

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Engineering Protein Coacervates into a Robust Adhesive for Real-Time Skin Healing Article

Ming Li, Baimei Liu, Wei Xu, Lai Zhao, Zili Wang, Haonan He, Jingjing Li, Fan Wang, Chao Ma, Kai Liu, Hongjie Zhang

Engineering 2023, Volume 31, Issue 12,   Pages 76-85 doi: 10.1016/j.eng.2023.07.013

Abstract: biocomposite adhesive, with the active involvement of supramolecular interactions between chimeric proteinand natural DNA, leading to a robustly reinforced adhesion performance.

Keywords： Biocomposite adhesive     Protein     DNA     Coacervates     Skin healing    

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Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 136-140 doi: 10.1007/s11684-009-0029-2

Abstract: The objective of this study was to investigate the effects of resistin on insulin signaling in human umbilical vein endothelial cells (HUVECs). HUVECs were incubated with recombinant human resistin (0-100 ng/mL) for 24 h. Akt and endothelial nitric oxide synthase (eNOS) phosphorylation levels of endothelial cells under basal or insulin stimulated conditions were measured by Western blot. Nitric oxide (NO) production of HUVECs was also detected. The results showed that resistin could significantly inhibit Akt and eNOS phosphorylation and NO production in endothelial cells under insulin stimulated conditions ( < 0.05 control). But under basal conditions, treatment with resistin could result in a decrease in eNOS phosphorylation ( < 0.05 control) but had no effect on NO production and Akt phosphorylation levels. These findings suggested that resistin exerted an inhibitory effect on NO production by inhibiting insulin signaling and eNOS phosphorylation in endothelial cells.

Keywords： resistin     endothelium     nitric oxide     endothelial nitric oxide synthase     Akt-binding protein     mouse    

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Asymmetric transfer hydrogenation of prochiral ketone catalyzed over Fe-CS/SBA-15 catalyst

XUE Ping, WU Tao

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 3,   Pages 251-255 doi: 10.1007/s11705-007-0045-1

Abstract: A heterogeneous chiral catalyst Fe(III)-CS (chitosan) complex/mesoporous molecular sieve SBA-15 (Santaprochiral acetophenone and 4-methyl-2-pentanone to corresponding chiral alcohols were carried out on Fe-CSFe-CS/SBA-15 with 2.2% mass fraction Fe exhibits considerable enantioselectivity and catalytic activity

Keywords： asymmetric transfer     enantioselectivity     Fe-CS/SBA-15     aliphatic     aromatic    

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Chloride binding and time-dependent surface chloride content models for fly ash concrete

S. MUTHULINGAM,B. N. RAO

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 1,   Pages 112-120 doi: 10.1007/s11709-015-0322-x

Abstract: fly ash concrete, namely: 1) surface chloride content under tidal exposure condition; and 2) chloride bindingFirst, inconsistencies in surface chloride content and chloride binding models reported in literatureSecondly, to avoid such inconsistencies, surface chloride content and chloride binding models for fly

Keywords： binding isotherms     chloride ingress     concrete     fly ash     surface chloride content    

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Gradient-based compressive image fusion

Yang CHEN,Zheng QIN

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 3,   Pages 227-237 doi: 10.1631/FITEE.1400217

Abstract: We present a novel image fusion scheme based on gradient and scrambled block Hadamard ensemble (SBHE) sampling for compressive sensing imaging. First, source images are compressed by compressive sensing, to facilitate the transmission of the sensor. In the fusion phase, the image gradient is calculated to reflect the abundance of its contour information. By compositing the gradient of each image, gradient-based weights are obtained, with which compressive sensing coefficients are achieved. Finally, inverse transformation is applied to the coefficients derived from fusion, and the fused image is obtained. Information entropy (IE), Xydeas’s and Piella’s metrics are applied as non-reference objective metrics to evaluate the fusion quality in line with different fusion schemes. In addition, different image fusion application scenarios are applied to explore the scenario adaptability of the proposed scheme. Simulation results demonstrate that the gradient-based scheme has the best performance, in terms of both subjective judgment and objective metrics. Furthermore, the gradient-based fusion scheme proposed in this paper can be applied in different fusion scenarios.

Keywords： Compressive sensing (CS)     Image fusion     Gradient-based image fusion     CS-based image fusion    

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Influence of Tensile Overload on Fatigue Life of LC4CS Al-alloy After Corrosion

Jiang Hui,Yang Xiaohua

Strategic Study of CAE 2006, Volume 8, Issue 2,   Pages 44-46

Abstract:

Having undergone accelerative calendar corrosion, a plate with a central hole of LC4CS alloy was subjected

Keywords： LC4CS Al-alloy     corrosion before loads     overload     fatigue life    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development of

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Title Author Date Type Operation

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

Molecular simulation of the interaction mechanism between CodY protein and DNA in

Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

Anti RNA Viruses Related Biomaterials

Yao Kangde,Yin Yuji,Zhang Baolian,Zhao Liguo

Journal Article

Protein adsorption in two-dimensional electrochromatography packed with superporous and microporous cellulose

Dongmei WANG, Guodong JIA, Liang XU, Xiaoyan DONG, Yan SUN

Journal Article

Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Journal Article

Engineering Protein Coacervates into a Robust Adhesive for Real-Time Skin Healing

Ming Li, Baimei Liu, Wei Xu, Lai Zhao, Zili Wang, Haonan He, Jingjing Li, Fan Wang, Chao Ma, Kai Liu, Hongjie Zhang

Journal Article

Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Journal Article

Asymmetric transfer hydrogenation of prochiral ketone catalyzed over Fe-CS/SBA-15 catalyst

XUE Ping, WU Tao

Journal Article

Chloride binding and time-dependent surface chloride content models for fly ash concrete

S. MUTHULINGAM,B. N. RAO

Journal Article

Gradient-based compressive image fusion

Yang CHEN,Zheng QIN

Journal Article

Influence of Tensile Overload on Fatigue Life of LC4CS Al-alloy After Corrosion

Jiang Hui,Yang Xiaohua

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article